rs743811
Variant in the HMOX1 gene (Heme Oxygenase 1)
rs743811 is a single nucleotide polymorphism (SNP) in the HMOX1 gene, involved in heme catabolism and cytoprotection. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs743811 variant?
rs743811 is a SNP (single nucleotide polymorphism) in the HMOX1 (Heme Oxygenase 1) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. HMOX1 encodes heme oxygenase-1, an inducible enzyme that degrades heme to produce carbon monoxide, biliverdin, and free iron, providing cytoprotection.
Biological role and pathway
This variant sits within the HMOX1 gene, which is involved in the heme catabolism and cytoprotection pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs743811 and Long COVID / ME-CFS research
HMOX1 induction is a key adaptive response to oxidative and inflammatory stress; variants may influence resilience to Long COVID-related cellular damage.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HMOX1
rs743811 is one of 2 known variants in the HMOX1 gene. To understand the full biological context of this variant, explore the parent gene page.
View HMOX1 gene page →Conditions studied in relation to rs743811
Research into HMOX1 variants including rs743811 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HMOX1 and the rs743811 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HMOX1 gene
The following variants in HMOX1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs743811 variant in the HMOX1 gene?
rs743811 is a single nucleotide polymorphism (SNP) located in the HMOX1 (Heme Oxygenase 1) gene, which is involved in heme catabolism and cytoprotection. HMOX1 encodes heme oxygenase-1, an inducible enzyme that degrades heme to produce carbon monoxide, biliverdin, and free iron, providing cytoprotection.
How may the rs743811 variant relate to Long COVID or ME/CFS?
HMOX1 induction is a key adaptive response to oxidative and inflammatory stress; variants may influence resilience to Long COVID-related cellular damage.
Can a consumer DNA test detect the rs743811 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs743811 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for HMOX1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25122754
- [2]Nature Genetics
- [3]Journal of Clinical Investigation