rs12086634
Variant in the HSD11B1 gene (Hydroxysteroid 11-Beta Dehydrogenase 1)
rs12086634 is a single nucleotide polymorphism (SNP) in the HSD11B1 gene, involved in cortisol regeneration / glucocorticoid tissue amplification. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs12086634 variant?
rs12086634 is a SNP (single nucleotide polymorphism) in the HSD11B1 (Hydroxysteroid 11-Beta Dehydrogenase 1) gene. It belongs to the Metabolic category and is part of the Autonomic Nervous System biological cluster. HSD11B1 encodes 11β-hydroxysteroid dehydrogenase 1, which converts inactive cortisone to active cortisol in tissues, amplifying local glucocorticoid signaling.
Biological role and pathway
This variant sits within the HSD11B1 gene, which is involved in the cortisol regeneration / glucocorticoid tissue amplification pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs12086634 and Long COVID / ME-CFS research
HSD11B1 amplifies local cortisol in adipose and brain; variants affecting tissue glucocorticoid levels may influence the HPA axis-driven fatigue and immune regulation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HSD11B1
rs12086634 is one of 2 known variants in the HSD11B1 gene. To understand the full biological context of this variant, explore the parent gene page.
View HSD11B1 gene page →Conditions studied in relation to rs12086634
Research into HSD11B1 variants including rs12086634 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HSD11B1 and the rs12086634 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HSD11B1 gene
The following variants in HSD11B1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs12086634 variant in the HSD11B1 gene?
rs12086634 is a single nucleotide polymorphism (SNP) located in the HSD11B1 (Hydroxysteroid 11-Beta Dehydrogenase 1) gene, which is involved in cortisol regeneration / glucocorticoid tissue amplification. HSD11B1 encodes 11β-hydroxysteroid dehydrogenase 1, which converts inactive cortisone to active cortisol in tissues, amplifying local glucocorticoid signaling.
How may the rs12086634 variant relate to Long COVID or ME/CFS?
HSD11B1 amplifies local cortisol in adipose and brain; variants affecting tissue glucocorticoid levels may influence the HPA axis-driven fatigue and immune regulation in Long COVID.
Can a consumer DNA test detect the rs12086634 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs12086634 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for HSD11B1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Psychoneuroendocrinology