rs7359479

What is the rs7359479 variant?

rs7359479 is a SNP (single nucleotide polymorphism) in the HSD11B1 (Hydroxysteroid 11-Beta Dehydrogenase 1) gene. It belongs to the Metabolic category and is part of the Autonomic Nervous System biological cluster. HSD11B1 encodes 11β-hydroxysteroid dehydrogenase 1, which converts inactive cortisone to active cortisol in tissues, amplifying local glucocorticoid signaling.

Biological role and pathway

This variant sits within the HSD11B1 gene, which is involved in the cortisol regeneration / glucocorticoid tissue amplification pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HSD11B1

rs7359479 is one of 2 known variants in the HSD11B1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs7359479

Research into HSD11B1 variants including rs7359479 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HSD11B1 and the rs7359479 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the HSD11B1 gene

The following variants in HSD11B1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions