rs34931611

What is the rs34931611 variant?

rs34931611 is a SNP (single nucleotide polymorphism) in the IDH1 (Isocitrate Dehydrogenase 1) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. IDH1 encodes cytosolic isocitrate dehydrogenase 1, which generates NADPH through the TCA cycle reaction.

Biological role and pathway

This variant sits within the IDH1 gene, which is involved in the TCA cycle / redox metabolism pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IDH1

rs34931611 is one of 1 known variant in the IDH1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs34931611

Research into IDH1 variants including rs34931611 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IDH1 and the rs34931611 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions