rs11632671
Variant in the IDH2 gene (Isocitrate Dehydrogenase 2 (Mitochondrial))
rs11632671 is a single nucleotide polymorphism (SNP) in the IDH2 gene, involved in TCA cycle / mitochondrial NADPH generation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11632671 variant?
rs11632671 is a SNP (single nucleotide polymorphism) in the IDH2 (Isocitrate Dehydrogenase 2 (Mitochondrial)) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. IDH2 encodes mitochondrial isocitrate dehydrogenase 2, which generates NADPH for mitochondrial antioxidant defense.
Biological role and pathway
This variant sits within the IDH2 gene, which is involved in the TCA cycle / mitochondrial NADPH generation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11632671 and Long COVID / ME-CFS research
IDH2-derived mitochondrial NADPH is critical for managing oxidative stress in mitochondria; variants may impair mitochondrial antioxidant capacity in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IDH2
rs11632671 is one of 1 known variant in the IDH2 gene. To understand the full biological context of this variant, explore the parent gene page.
View IDH2 gene page →Conditions studied in relation to rs11632671
Research into IDH2 variants including rs11632671 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IDH2 and the rs11632671 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs11632671 variant in the IDH2 gene?
rs11632671 is a single nucleotide polymorphism (SNP) located in the IDH2 (Isocitrate Dehydrogenase 2 (Mitochondrial)) gene, which is involved in TCA cycle / mitochondrial NADPH generation. IDH2 encodes mitochondrial isocitrate dehydrogenase 2, which generates NADPH for mitochondrial antioxidant defense.
How may the rs11632671 variant relate to Long COVID or ME/CFS?
IDH2-derived mitochondrial NADPH is critical for managing oxidative stress in mitochondria; variants may impair mitochondrial antioxidant capacity in Long COVID.
Can a consumer DNA test detect the rs11632671 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11632671 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IDH2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Cell Metabolism