rs11171739

What is the rs11171739 variant?

rs11171739 is a SNP (single nucleotide polymorphism) in the IL25 (Interleukin 25 (IL-17E)) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL25 encodes IL-17E, an alarmin released by barrier epithelial cells that amplifies Th2 responses and mast cell activation.

Biological role and pathway

This variant sits within the IL25 gene, which is involved in the barrier immunity and Th2 amplification pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IL25

rs11171739 is one of 1 known variant in the IL25 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs11171739

Research into IL25 variants including rs11171739 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL25 and the rs11171739 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the IL25 gene

The following variants in IL25 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions