rs9313422
Variant in the IL25 gene (Interleukin 25 (IL-17E))
rs9313422 is a single nucleotide polymorphism (SNP) in the IL25 gene, involved in type-2 immune response initiation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9313422 variant?
rs9313422 is a SNP (single nucleotide polymorphism) in the IL25 (Interleukin 25 (IL-17E)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL25 encodes IL-17E/IL-25, an epithelial-derived cytokine that promotes type-2 immunity by activating ILC2s and mast cells.
Biological role and pathway
This variant sits within the IL25 gene, which is involved in the type-2 immune response initiation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9313422 and Long COVID / ME-CFS research
IL-25 promotes type-2 inflammation alongside IL-33 and TSLP; variants may affect mast cell and ILC2 responses relevant to histamine intolerance and MCAS in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL25
rs9313422 is one of 1 known variant in the IL25 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL25 gene page →Conditions studied in relation to rs9313422
Research into IL25 variants including rs9313422 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL25 and the rs9313422 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL25 gene
The following variants in IL25 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs9313422 variant in the IL25 gene?
rs9313422 is a single nucleotide polymorphism (SNP) located in the IL25 (Interleukin 25 (IL-17E)) gene, which is involved in type-2 immune response initiation. IL25 encodes IL-17E/IL-25, an epithelial-derived cytokine that promotes type-2 immunity by activating ILC2s and mast cells.
How may the rs9313422 variant relate to Long COVID or ME/CFS?
IL-25 promotes type-2 inflammation alongside IL-33 and TSLP; variants may affect mast cell and ILC2 responses relevant to histamine intolerance and MCAS in Long COVID.
Can a consumer DNA test detect the rs9313422 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9313422 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IL25 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33398161
- [2]Nature Immunology
- [3]Journal of Allergy and Clinical Immunology