rs153109
Variant in the IL27 gene (Interleukin 27)
rs153109 is a single nucleotide polymorphism (SNP) in the IL27 gene, involved in IL-27/STAT1/STAT3 immune regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs153109 variant?
rs153109 is a SNP (single nucleotide polymorphism) in the IL27 (Interleukin 27) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL27 encodes interleukin-27, a heterodimeric cytokine with both pro-inflammatory (inducing Th1) and anti-inflammatory (inducing Tr1) effects.
Biological role and pathway
This variant sits within the IL27 gene, which is involved in the IL-27/STAT1/STAT3 immune regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs153109 and Long COVID / ME-CFS research
IL-27 balances antiviral Th1 responses and immune regulation; variants may affect T helper cell differentiation and the resolution of chronic immune activation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL27
rs153109 is one of 2 known variants in the IL27 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL27 gene page →Conditions studied in relation to rs153109
Research into IL27 variants including rs153109 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL27 and the rs153109 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL27 gene
The following variants in IL27 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs153109 variant in the IL27 gene?
rs153109 is a single nucleotide polymorphism (SNP) located in the IL27 (Interleukin 27) gene, which is involved in IL-27/STAT1/STAT3 immune regulation. IL27 encodes interleukin-27, a heterodimeric cytokine with both pro-inflammatory (inducing Th1) and anti-inflammatory (inducing Tr1) effects.
How may the rs153109 variant relate to Long COVID or ME/CFS?
IL-27 balances antiviral Th1 responses and immune regulation; variants may affect T helper cell differentiation and the resolution of chronic immune activation in Long COVID.
Can a consumer DNA test detect the rs153109 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs153109 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL27 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Immunology
- [3]Journal of Immunology