rs181206
Variant in the IL27 gene (Interleukin 27)
rs181206 is a single nucleotide polymorphism (SNP) in the IL27 gene, involved in T helper cell regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs181206 variant?
rs181206 is a SNP (single nucleotide polymorphism) in the IL27 (Interleukin 27) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL27 encodes an immunomodulatory cytokine that regulates Th1/Th17 balance and can suppress excessive inflammation.
Biological role and pathway
This variant sits within the IL27 gene, which is involved in the T helper cell regulation pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs181206 and Long COVID / ME-CFS research
IL27 anti-inflammatory activity may help regulate persistent inflammatory responses; variants may affect immune homeostasis in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL27
rs181206 is one of 2 known variants in the IL27 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL27 gene page →Conditions studied in relation to rs181206
Research into IL27 variants including rs181206 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL27 and the rs181206 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL27 gene
The following variants in IL27 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs181206 variant in the IL27 gene?
rs181206 is a single nucleotide polymorphism (SNP) located in the IL27 (Interleukin 27) gene, which is involved in T helper cell regulation. IL27 encodes an immunomodulatory cytokine that regulates Th1/Th17 balance and can suppress excessive inflammation.
How may the rs181206 variant relate to Long COVID or ME/CFS?
IL27 anti-inflammatory activity may help regulate persistent inflammatory responses; variants may affect immune homeostasis in Long COVID.
Can a consumer DNA test detect the rs181206 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs181206 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL27 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation