rs10892318
Variant in the LCK gene (LCK Proto-Oncogene Src Family Tyrosine Kinase)
rs10892318 is a single nucleotide polymorphism (SNP) in the LCK gene, involved in T cell receptor proximal signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs10892318 variant?
rs10892318 is a SNP (single nucleotide polymorphism) in the LCK (LCK Proto-Oncogene Src Family Tyrosine Kinase) gene. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. LCK encodes Lck, the Src family kinase that initiates TCR signaling by phosphorylating CD3 ITAMs.
Biological role and pathway
This variant sits within the LCK gene, which is involved in the T cell receptor proximal signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs10892318 and Long COVID / ME-CFS research
Lck initiates T cell activation signaling; variants may affect TCR sensitivity and T cell activation thresholds relevant to immune dysregulation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: LCK
rs10892318 is one of 1 known variant in the LCK gene. To understand the full biological context of this variant, explore the parent gene page.
View LCK gene page →Conditions studied in relation to rs10892318
Research into LCK variants including rs10892318 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LCK and the rs10892318 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the LCK gene
The following variants in LCK are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs10892318 variant in the LCK gene?
rs10892318 is a single nucleotide polymorphism (SNP) located in the LCK (LCK Proto-Oncogene Src Family Tyrosine Kinase) gene, which is involved in T cell receptor proximal signaling. LCK encodes Lck, the Src family kinase that initiates TCR signaling by phosphorylating CD3 ITAMs.
How may the rs10892318 variant relate to Long COVID or ME/CFS?
Lck initiates T cell activation signaling; variants may affect TCR sensitivity and T cell activation thresholds relevant to immune dysregulation in Long COVID.
Can a consumer DNA test detect the rs10892318 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs10892318 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for LCK and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Immunology