rs3026522
Variant in the LCK gene (LCK Proto-Oncogene, Src Family Tyrosine Kinase)
rs3026522 is a single nucleotide polymorphism (SNP) in the LCK gene, involved in T cell receptor signaling initiation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3026522 variant?
rs3026522 is a SNP (single nucleotide polymorphism) in the LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase) gene. It belongs to the Lymphocyte category and is part of the Lymphocyte Biology biological cluster. LCK encodes a Src family tyrosine kinase that initiates TCR signaling by phosphorylating CD3 zeta ITAMs upon antigen recognition.
Biological role and pathway
This variant sits within the LCK gene, which is involved in the T cell receptor signaling initiation pathway. Genes within the Lymphocyte Biology cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3026522 and Long COVID / ME-CFS research
LCK signaling initiates T cell activation; variants may affect TCR sensitivity and T cell response thresholds in Long COVID immune dysregulation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: LCK
rs3026522 is one of 1 known variant in the LCK gene. To understand the full biological context of this variant, explore the parent gene page.
View LCK gene page →Conditions studied in relation to rs3026522
Research into LCK variants including rs3026522 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LCK and the rs3026522 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the LCK gene
The following variants in LCK are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3026522 variant in the LCK gene?
rs3026522 is a single nucleotide polymorphism (SNP) located in the LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase) gene, which is involved in T cell receptor signaling initiation. LCK encodes a Src family tyrosine kinase that initiates TCR signaling by phosphorylating CD3 zeta ITAMs upon antigen recognition.
How may the rs3026522 variant relate to Long COVID or ME/CFS?
LCK signaling initiates T cell activation; variants may affect TCR sensitivity and T cell response thresholds in Long COVID immune dysregulation.
Can a consumer DNA test detect the rs3026522 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3026522 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for LCK and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation