rs11875065
Variant in the LGP2 gene (Laboratory Of Genetics And Physiology 2)
rs11875065 is a single nucleotide polymorphism (SNP) in the LGP2 gene, involved in RLR signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11875065 variant?
rs11875065 is a SNP (single nucleotide polymorphism) in the LGP2 (Laboratory Of Genetics And Physiology 2) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. LGP2 (DHX58) is a DExH RNA helicase related to RIG-I and MDA5. It lacks signaling CARDs but regulates RNA sensing by facilitating MDA5 filament assembly and modulating RIG-I signaling amplitude.
Biological role and pathway
This variant sits within the LGP2 gene, which is involved in the RLR signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11875065 and Long COVID / ME-CFS research
LGP2 fine-tunes antiviral RNA sensing thresholds. Its regulatory role in MDA5-mediated long dsRNA sensing may influence COVID-19 innate immune responses, as MDA5 is a primary sensor for coronaviruses including SARS-CoV-2.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: LGP2
rs11875065 is one of 2 known variants in the LGP2 gene. To understand the full biological context of this variant, explore the parent gene page.
View LGP2 gene page →Conditions studied in relation to rs11875065
Research into LGP2 variants including rs11875065 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LGP2 and the rs11875065 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the LGP2 gene
The following variants in LGP2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11875065 variant in the LGP2 gene?
rs11875065 is a single nucleotide polymorphism (SNP) located in the LGP2 (Laboratory Of Genetics And Physiology 2) gene, which is involved in RLR signaling. LGP2 (DHX58) is a DExH RNA helicase related to RIG-I and MDA5. It lacks signaling CARDs but regulates RNA sensing by facilitating MDA5 filament assembly and modulating RIG-I signaling amplitude.
How may the rs11875065 variant relate to Long COVID or ME/CFS?
LGP2 fine-tunes antiviral RNA sensing thresholds. Its regulatory role in MDA5-mediated long dsRNA sensing may influence COVID-19 innate immune responses, as MDA5 is a primary sensor for coronaviruses including SARS-CoV-2.
Can a consumer DNA test detect the rs11875065 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11875065 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for LGP2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25416875
- [2]Nature Immunology
- [3]Cell