rs10490770
Variant in the LZTFL1 gene (Leucine Zipper Transcription Factor Like 1)
rs10490770 is a single nucleotide polymorphism (SNP) in the LZTFL1 gene, involved in STING/innate immune signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs10490770 variant?
rs10490770 is a SNP (single nucleotide polymorphism) in the LZTFL1 (Leucine Zipper Transcription Factor Like 1) gene. It belongs to the Immune Signaling category and is part of the Viral Defense & Interferon Response biological cluster. LZTFL1 is located in the 3p21.31 chromosomal locus, a major COVID-19 susceptibility region identified in GWAS studies.
Biological role and pathway
This variant sits within the LZTFL1 gene, which is involved in the STING/innate immune signaling pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs10490770 and Long COVID / ME-CFS research
The 3p21.31 locus containing LZTFL1 is among the strongest genetic risk factors for severe COVID-19, potentially influencing Long COVID susceptibility through innate immune dysregulation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: LZTFL1
rs10490770 is one of 2 known variants in the LZTFL1 gene. To understand the full biological context of this variant, explore the parent gene page.
View LZTFL1 gene page →Conditions studied in relation to rs10490770
Research into LZTFL1 variants including rs10490770 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LZTFL1 and the rs10490770 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the LZTFL1 gene
The following variants in LZTFL1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs10490770 variant in the LZTFL1 gene?
rs10490770 is a single nucleotide polymorphism (SNP) located in the LZTFL1 (Leucine Zipper Transcription Factor Like 1) gene, which is involved in STING/innate immune signaling. LZTFL1 is located in the 3p21.31 chromosomal locus, a major COVID-19 susceptibility region identified in GWAS studies.
How may the rs10490770 variant relate to Long COVID or ME/CFS?
The 3p21.31 locus containing LZTFL1 is among the strongest genetic risk factors for severe COVID-19, potentially influencing Long COVID susceptibility through innate immune dysregulation.
Can a consumer DNA test detect the rs10490770 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs10490770 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for LZTFL1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32558485
- [2]Nature
- [3]Nature Genetics