rs1358948

What is the rs1358948 variant?

rs1358948 is a SNP (single nucleotide polymorphism) in the MAPK14 (Mitogen-Activated Protein Kinase 14 (p38-alpha)) gene. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. MAPK14 encodes p38α MAP kinase, a central stress-activated kinase that drives inflammatory cytokine production in response to various stimuli.

Biological role and pathway

This variant sits within the MAPK14 gene, which is involved in the p38 MAPK stress and inflammatory signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MAPK14

rs1358948 is one of 1 known variant in the MAPK14 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1358948

Research into MAPK14 variants including rs1358948 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MAPK14 and the rs1358948 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the MAPK14 gene

The following variants in MAPK14 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions