rs2333227
Variant in the MPO gene (Myeloperoxidase)
rs2333227 is a single nucleotide polymorphism (SNP) in the MPO gene, involved in oxidative burst. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2333227 variant?
rs2333227 is a SNP (single nucleotide polymorphism) in the MPO (Myeloperoxidase) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. MPO is a heme enzyme in neutrophil granules that generates hypochlorous acid (HOCl) and other oxidants during the respiratory burst, contributing to antimicrobial defense and NET formation.
Biological role and pathway
This variant sits within the MPO gene, which is involved in the oxidative burst pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2333227 and Long COVID / ME-CFS research
MPO-DNA complexes are elevated in Long COVID blood, serving as biomarkers of ongoing NET formation. MPO variants affecting enzymatic activity may influence the degree of oxidative tissue damage and NETosis in post-COVID vascular disease.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MPO
rs2333227 is one of 3 known variants in the MPO gene. To understand the full biological context of this variant, explore the parent gene page.
View MPO gene page →Conditions studied in relation to rs2333227
Research into MPO variants including rs2333227 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MPO and the rs2333227 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MPO gene
The following variants in MPO are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2333227 variant in the MPO gene?
rs2333227 is a single nucleotide polymorphism (SNP) located in the MPO (Myeloperoxidase) gene, which is involved in oxidative burst. MPO is a heme enzyme in neutrophil granules that generates hypochlorous acid (HOCl) and other oxidants during the respiratory burst, contributing to antimicrobial defense and NET formation.
How may the rs2333227 variant relate to Long COVID or ME/CFS?
MPO-DNA complexes are elevated in Long COVID blood, serving as biomarkers of ongoing NET formation. MPO variants affecting enzymatic activity may influence the degree of oxidative tissue damage and NETosis in post-COVID vascular disease.
Can a consumer DNA test detect the rs2333227 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2333227 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MPO and its variants. This is not an exhaustive literature review.
- [1]PMID: 32926228
- [2]Journal of Thrombosis and Haemostasis
- [3]Redox Biology