rs1441586
Variant in the MS4A2 gene (Membrane Spanning 4-Domains A2)
rs1441586 is a single nucleotide polymorphism (SNP) in the MS4A2 gene, involved in mast cell activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1441586 variant?
rs1441586 is a SNP (single nucleotide polymorphism) in the MS4A2 (Membrane Spanning 4-Domains A2) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. MS4A2 encodes FcεRIβ, the beta chain of the high-affinity IgE receptor on mast cells and basophils. It amplifies IgE-mediated signaling and variants are associated with atopic disease susceptibility.
Biological role and pathway
This variant sits within the MS4A2 gene, which is involved in the mast cell activation pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1441586 and Long COVID / ME-CFS research
Mast cell activation syndrome (MCAS) is increasingly recognized in Long COVID, with symptoms of histamine excess including flushing, urticaria, GI disturbance, and cardiovascular instability. MS4A2 variants affecting mast cell IgE receptor sensitivity may contribute to MCAS-like features in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MS4A2
rs1441586 is one of 3 known variants in the MS4A2 gene. To understand the full biological context of this variant, explore the parent gene page.
View MS4A2 gene page →Conditions studied in relation to rs1441586
Research into MS4A2 variants including rs1441586 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MS4A2 and the rs1441586 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MS4A2 gene
The following variants in MS4A2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1441586 variant in the MS4A2 gene?
rs1441586 is a single nucleotide polymorphism (SNP) located in the MS4A2 (Membrane Spanning 4-Domains A2) gene, which is involved in mast cell activation. MS4A2 encodes FcεRIβ, the beta chain of the high-affinity IgE receptor on mast cells and basophils. It amplifies IgE-mediated signaling and variants are associated with atopic disease susceptibility.
How may the rs1441586 variant relate to Long COVID or ME/CFS?
Mast cell activation syndrome (MCAS) is increasingly recognized in Long COVID, with symptoms of histamine excess including flushing, urticaria, GI disturbance, and cardiovascular instability. MS4A2 variants affecting mast cell IgE receptor sensitivity may contribute to MCAS-like features in Long COVID.
Can a consumer DNA test detect the rs1441586 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Related articles
- Long COVID MCAS: Mast Cells, Histamine and Your Genes
Learn how Long COVID MCAS may develop, how it overlaps with POTS and histamine intolerance, and which genes research links to mast cell activity.
Find out if you carry the rs1441586 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MS4A2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29548640
- [2]Journal of Allergy and Clinical Immunology
- [3]Nature Immunology