rs512555

What is the rs512555 variant?

rs512555 is a SNP (single nucleotide polymorphism) in the MS4A2 (Membrane Spanning 4-Domains A2 (FcεRI-beta)) gene. It belongs to the Immune Signaling category and is part of the Histamine & MCAS biological cluster. MS4A2 encodes the beta subunit of the high-affinity IgE receptor (FcεRI), which is expressed on mast cells and basophils and amplifies IgE-mediated activation.

Biological role and pathway

This variant sits within the MS4A2 gene, which is involved in the high-affinity IgE receptor / mast cell activation pathway. Genes within the Histamine & MCAS cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MS4A2

rs512555 is one of 3 known variants in the MS4A2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs512555

Research into MS4A2 variants including rs512555 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MS4A2 and the rs512555 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the MS4A2 gene

The following variants in MS4A2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions

Related articles

• Long COVID MCAS: Mast Cells, Histamine and Your Genes

  Learn how Long COVID MCAS may develop, how it overlaps with POTS and histamine intolerance, and which genes research links to mast cell activity.