rs2295080
Variant in the MTOR gene (Mechanistic Target Of Rapamycin Kinase)
rs2295080 is a single nucleotide polymorphism (SNP) in the MTOR gene, involved in mTOR signaling / cellular growth and metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2295080 variant?
rs2295080 is a SNP (single nucleotide polymorphism) in the MTOR (Mechanistic Target Of Rapamycin Kinase) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. MTOR encodes the catalytic subunit of mTORC1 and mTORC2, master regulators of cell growth, metabolism, and autophagy.
Biological role and pathway
This variant sits within the MTOR gene, which is involved in the mTOR signaling / cellular growth and metabolism pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2295080 and Long COVID / ME-CFS research
mTOR is a key integrator of nutrient and energy signals; dysregulated mTOR activity may contribute to impaired autophagy, immune dysfunction, and metabolic abnormalities in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MTOR
rs2295080 is one of 2 known variants in the MTOR gene. To understand the full biological context of this variant, explore the parent gene page.
View MTOR gene page →Conditions studied in relation to rs2295080
Research into MTOR variants including rs2295080 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MTOR and the rs2295080 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MTOR gene
The following variants in MTOR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2295080 variant in the MTOR gene?
rs2295080 is a single nucleotide polymorphism (SNP) located in the MTOR (Mechanistic Target Of Rapamycin Kinase) gene, which is involved in mTOR signaling / cellular growth and metabolism. MTOR encodes the catalytic subunit of mTORC1 and mTORC2, master regulators of cell growth, metabolism, and autophagy.
How may the rs2295080 variant relate to Long COVID or ME/CFS?
mTOR is a key integrator of nutrient and energy signals; dysregulated mTOR activity may contribute to impaired autophagy, immune dysfunction, and metabolic abnormalities in Long COVID.
Can a consumer DNA test detect the rs2295080 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2295080 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MTOR and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Cell
- [3]Nature