rs11150303
Variant in the MUC2 gene (Mucin 2)
rs11150303 is a single nucleotide polymorphism (SNP) in the MUC2 gene, involved in intestinal mucus barrier. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11150303 variant?
rs11150303 is a SNP (single nucleotide polymorphism) in the MUC2 (Mucin 2) gene. It belongs to the Gut Microbiome category and is part of the Gut & Microbiome Interaction biological cluster. MUC2 encodes the major secreted gel-forming mucin in the intestine, forming the protective mucus layer separating bacteria from epithelium.
Biological role and pathway
This variant sits within the MUC2 gene, which is involved in the intestinal mucus barrier pathway. Genes within the Gut & Microbiome Interaction cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11150303 and Long COVID / ME-CFS research
MUC2 barrier function protects against microbial translocation; variants may contribute to gut dysbiosis and systemic inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MUC2
rs11150303 is one of 2 known variants in the MUC2 gene. To understand the full biological context of this variant, explore the parent gene page.
View MUC2 gene page →Conditions studied in relation to rs11150303
Research into MUC2 variants including rs11150303 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MUC2 and the rs11150303 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MUC2 gene
The following variants in MUC2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11150303 variant in the MUC2 gene?
rs11150303 is a single nucleotide polymorphism (SNP) located in the MUC2 (Mucin 2) gene, which is involved in intestinal mucus barrier. MUC2 encodes the major secreted gel-forming mucin in the intestine, forming the protective mucus layer separating bacteria from epithelium.
How may the rs11150303 variant relate to Long COVID or ME/CFS?
MUC2 barrier function protects against microbial translocation; variants may contribute to gut dysbiosis and systemic inflammation in Long COVID.
Can a consumer DNA test detect the rs11150303 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11150303 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MUC2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29925876
- [2]Nature Genetics
- [3]Journal of Clinical Investigation