rs4077759
Variant in the MUC2 gene (Mucin 2, Oligomeric Mucus/Gel-Forming)
rs4077759 is a single nucleotide polymorphism (SNP) in the MUC2 gene, involved in mucus layer. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4077759 variant?
rs4077759 is a SNP (single nucleotide polymorphism) in the MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming) gene. It belongs to the Gut Barrier category and is part of the Gut-Brain Axis biological cluster. MUC2 is the major secreted gel-forming mucin of the intestinal mucus layer, produced by goblet cells. It forms a physical barrier preventing bacterial contact with intestinal epithelium and influences microbiome composition.
Biological role and pathway
This variant sits within the MUC2 gene, which is involved in the mucus layer pathway. Genes within the Gut-Brain Axis cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4077759 and Long COVID / ME-CFS research
Mucus layer defects are associated with increased microbial translocation. MUC2 expression is altered in gastrointestinal COVID-19, and variants affecting mucus production may influence gut microbiome stability and barrier integrity relevant to Long COVID GI symptoms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MUC2
rs4077759 is one of 2 known variants in the MUC2 gene. To understand the full biological context of this variant, explore the parent gene page.
View MUC2 gene page →Conditions studied in relation to rs4077759
Research into MUC2 variants including rs4077759 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MUC2 and the rs4077759 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MUC2 gene
The following variants in MUC2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4077759 variant in the MUC2 gene?
rs4077759 is a single nucleotide polymorphism (SNP) located in the MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming) gene, which is involved in mucus layer. MUC2 is the major secreted gel-forming mucin of the intestinal mucus layer, produced by goblet cells. It forms a physical barrier preventing bacterial contact with intestinal epithelium and influences microbiome composition.
How may the rs4077759 variant relate to Long COVID or ME/CFS?
Mucus layer defects are associated with increased microbial translocation. MUC2 expression is altered in gastrointestinal COVID-19, and variants affecting mucus production may influence gut microbiome stability and barrier integrity relevant to Long COVID GI symptoms.
Can a consumer DNA test detect the rs4077759 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4077759 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MUC2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29444985
- [2]Nature Reviews Gastroenterology
- [3]Gut