rs3219484
Variant in the MUTYH gene (MutY DNA Glycosylase)
rs3219484 is a single nucleotide polymorphism (SNP) in the MUTYH gene, involved in base excision repair. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3219484 variant?
rs3219484 is a SNP (single nucleotide polymorphism) in the MUTYH (MutY DNA Glycosylase) gene. It belongs to the Dna Repair category and is part of the DNA Repair biological cluster. MUTYH encodes a DNA glycosylase that removes adenine misincorporated opposite 8-oxoguanine, working alongside OGG1 to prevent oxidative DNA damage.
Biological role and pathway
This variant sits within the MUTYH gene, which is involved in the base excision repair pathway. Genes within the DNA Repair cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3219484 and Long COVID / ME-CFS research
MUTYH variants reducing oxidative DNA damage repair may increase genomic instability under the elevated reactive oxygen species in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MUTYH
rs3219484 is one of 2 known variants in the MUTYH gene. To understand the full biological context of this variant, explore the parent gene page.
View MUTYH gene page →Conditions studied in relation to rs3219484
Research into MUTYH variants including rs3219484 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MUTYH and the rs3219484 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MUTYH gene
The following variants in MUTYH are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3219484 variant in the MUTYH gene?
rs3219484 is a single nucleotide polymorphism (SNP) located in the MUTYH (MutY DNA Glycosylase) gene, which is involved in base excision repair. MUTYH encodes a DNA glycosylase that removes adenine misincorporated opposite 8-oxoguanine, working alongside OGG1 to prevent oxidative DNA damage.
How may the rs3219484 variant relate to Long COVID or ME/CFS?
MUTYH variants reducing oxidative DNA damage repair may increase genomic instability under the elevated reactive oxygen species in Long COVID.
Can a consumer DNA test detect the rs3219484 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3219484 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MUTYH and its variants. This is not an exhaustive literature review.
- [1]PMID: 26014458
- [2]Nature Genetics
- [3]Journal of Clinical Investigation