rs2071430
Variant in the MX1 gene (MX Dynamin-Like GTPase 1)
rs2071430 is a single nucleotide polymorphism (SNP) in the MX1 gene, involved in interferon-stimulated gene response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2071430 variant?
rs2071430 is a SNP (single nucleotide polymorphism) in the MX1 (MX Dynamin-Like GTPase 1) gene. It belongs to the Viral Defense category and is part of the Viral Defense & Interferon Response biological cluster. MX1 encodes a dynamin-like GTPase that inhibits a wide range of RNA viruses as part of the type I interferon response.
Biological role and pathway
This variant sits within the MX1 gene, which is involved in the interferon-stimulated gene response pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2071430 and Long COVID / ME-CFS research
MX1 expression is driven by interferon signaling and has been studied in relation to persistent antiviral immune activation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MX1
rs2071430 is one of 1 known variant in the MX1 gene. To understand the full biological context of this variant, explore the parent gene page.
View MX1 gene page →Conditions studied in relation to rs2071430
Research into MX1 variants including rs2071430 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MX1 and the rs2071430 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MX1 gene
The following variants in MX1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2071430 variant in the MX1 gene?
rs2071430 is a single nucleotide polymorphism (SNP) located in the MX1 (MX Dynamin-Like GTPase 1) gene, which is involved in interferon-stimulated gene response. MX1 encodes a dynamin-like GTPase that inhibits a wide range of RNA viruses as part of the type I interferon response.
How may the rs2071430 variant relate to Long COVID or ME/CFS?
MX1 expression is driven by interferon signaling and has been studied in relation to persistent antiviral immune activation in Long COVID.
Can a consumer DNA test detect the rs2071430 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2071430 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MX1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32972995
- [2]Nature Genetics
- [3]Journal of Clinical Investigation