rs469390
Variant in the MX1 gene (MX Dynamin Like GTPase 1)
rs469390 is a single nucleotide polymorphism (SNP) in the MX1 gene, involved in interferon-induced antiviral defense. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs469390 variant?
rs469390 is a SNP (single nucleotide polymorphism) in the MX1 (MX Dynamin Like GTPase 1) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. MX1 encodes a GTPase induced by type I interferons that inhibits replication of many RNA viruses by trapping viral nucleocapsids.
Biological role and pathway
This variant sits within the MX1 gene, which is involved in the interferon-induced antiviral defense pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs469390 and Long COVID / ME-CFS research
MX1 is a key antiviral effector of the type I interferon response; variants may affect the efficiency of innate antiviral defense against SARS-CoV-2.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: MX1
rs469390 is one of 1 known variant in the MX1 gene. To understand the full biological context of this variant, explore the parent gene page.
View MX1 gene page →Conditions studied in relation to rs469390
Research into MX1 variants including rs469390 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MX1 and the rs469390 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the MX1 gene
The following variants in MX1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs469390 variant in the MX1 gene?
rs469390 is a single nucleotide polymorphism (SNP) located in the MX1 (MX Dynamin Like GTPase 1) gene, which is involved in interferon-induced antiviral defense. MX1 encodes a GTPase induced by type I interferons that inhibits replication of many RNA viruses by trapping viral nucleocapsids.
How may the rs469390 variant relate to Long COVID or ME/CFS?
MX1 is a key antiviral effector of the type I interferon response; variants may affect the efficiency of innate antiviral defense against SARS-CoV-2.
Can a consumer DNA test detect the rs469390 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs469390 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for MX1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]Nature Genetics
- [3]Journal of Virology