rs61330082

What is the rs61330082 variant?

rs61330082 is a SNP (single nucleotide polymorphism) in the NAMPT (Nicotinamide Phosphoribosyltransferase) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. NAMPT encodes the rate-limiting enzyme in the NAD+ salvage pathway, converting nicotinamide to NMN; also secreted as a pro-inflammatory cytokine (eNAMPT/PBEF).

Biological role and pathway

This variant sits within the NAMPT gene, which is involved in the NAD+ biosynthesis / sirtuin activation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NAMPT

rs61330082 is one of 3 known variants in the NAMPT gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs61330082

Research into NAMPT variants including rs61330082 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NAMPT and the rs61330082 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the NAMPT gene

The following variants in NAMPT are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions