rs9770242
Variant in the NAMPT gene (Nicotinamide Phosphoribosyltransferase)
rs9770242 is a single nucleotide polymorphism (SNP) in the NAMPT gene, involved in NAD+ biosynthesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9770242 variant?
rs9770242 is a SNP (single nucleotide polymorphism) in the NAMPT (Nicotinamide Phosphoribosyltransferase) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. NAMPT is the rate-limiting enzyme in the NAD+ salvage pathway, converting nicotinamide to NMN and then NAD+. Both intracellular NAMPT and secreted eNAMPT have distinct metabolic and inflammatory roles.
Biological role and pathway
This variant sits within the NAMPT gene, which is involved in the NAD+ biosynthesis pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9770242 and Long COVID / ME-CFS research
NAD+ deficiency is implicated in Long COVID pathophysiology. NAMPT variants affecting NAD+ biosynthesis capacity may limit the cellular energy and repair processes needed for post-COVID recovery, potentially explaining persistent fatigue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NAMPT
rs9770242 is one of 3 known variants in the NAMPT gene. To understand the full biological context of this variant, explore the parent gene page.
View NAMPT gene page →Conditions studied in relation to rs9770242
Research into NAMPT variants including rs9770242 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NAMPT and the rs9770242 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NAMPT gene
The following variants in NAMPT are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs9770242 variant in the NAMPT gene?
rs9770242 is a single nucleotide polymorphism (SNP) located in the NAMPT (Nicotinamide Phosphoribosyltransferase) gene, which is involved in NAD+ biosynthesis. NAMPT is the rate-limiting enzyme in the NAD+ salvage pathway, converting nicotinamide to NMN and then NAD+. Both intracellular NAMPT and secreted eNAMPT have distinct metabolic and inflammatory roles.
How may the rs9770242 variant relate to Long COVID or ME/CFS?
NAD+ deficiency is implicated in Long COVID pathophysiology. NAMPT variants affecting NAD+ biosynthesis capacity may limit the cellular energy and repair processes needed for post-COVID recovery, potentially explaining persistent fatigue.
Can a consumer DNA test detect the rs9770242 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9770242 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NAMPT and its variants. This is not an exhaustive literature review.
- [1]PMID: 33597518
- [2]Cell Reports
- [3]Nature Metabolism