rs201802880

What is the rs201802880 variant?

rs201802880 is a SNP (single nucleotide polymorphism) in the NCF1 (Neutrophil Cytosol Factor 1 (p47phox)) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. NCF1 encodes p47phox, a cytosolic component of the phagocyte NADPH oxidase complex required for its activation.

Biological role and pathway

This variant sits within the NCF1 gene, which is involved in the NADPH oxidase complex assembly pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NCF1

rs201802880 is one of 1 known variant in the NCF1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs201802880

Research into NCF1 variants including rs201802880 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NCF1 and the rs201802880 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions