rs1130562
Variant in the NDUFA9 gene (NADH:Ubiquinone Oxidoreductase Subunit A9)
rs1130562 is a single nucleotide polymorphism (SNP) in the NDUFA9 gene, involved in oxidative phosphorylation Complex I. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1130562 variant?
rs1130562 is a SNP (single nucleotide polymorphism) in the NDUFA9 (NADH:Ubiquinone Oxidoreductase Subunit A9) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. NDUFA9 encodes an accessory subunit of NADH:ubiquinone oxidoreductase (Complex I) involved in its proper assembly and function.
Biological role and pathway
This variant sits within the NDUFA9 gene, which is involved in the oxidative phosphorylation Complex I pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1130562 and Long COVID / ME-CFS research
NDUFA9 contributions to Complex I assembly and function are relevant to the mitochondrial dysfunction underlying Long COVID fatigue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NDUFA9
rs1130562 is one of 1 known variant in the NDUFA9 gene. To understand the full biological context of this variant, explore the parent gene page.
View NDUFA9 gene page →Conditions studied in relation to rs1130562
Research into NDUFA9 variants including rs1130562 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NDUFA9 and the rs1130562 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1130562 variant in the NDUFA9 gene?
rs1130562 is a single nucleotide polymorphism (SNP) located in the NDUFA9 (NADH:Ubiquinone Oxidoreductase Subunit A9) gene, which is involved in oxidative phosphorylation Complex I. NDUFA9 encodes an accessory subunit of NADH:ubiquinone oxidoreductase (Complex I) involved in its proper assembly and function.
How may the rs1130562 variant relate to Long COVID or ME/CFS?
NDUFA9 contributions to Complex I assembly and function are relevant to the mitochondrial dysfunction underlying Long COVID fatigue.
Can a consumer DNA test detect the rs1130562 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1130562 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NDUFA9 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation