rs6721961

What is the rs6721961 variant?

rs6721961 is a SNP (single nucleotide polymorphism) in the NRF2 (Nuclear Factor Erythroid 2-Like 2 (Nrf2)) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. NRF2 is the master transcription factor activating antioxidant gene programs in response to oxidative and electrophilic stress.

Biological role and pathway

This variant sits within the NRF2 gene, which is involved in the antioxidant response element signaling pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NRF2

rs6721961 is one of 2 known variants in the NRF2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs6721961

Research into NRF2 variants including rs6721961 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NRF2 and the rs6721961 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the NRF2 gene

The following variants in NRF2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions