rs1799983

What is the rs1799983 variant?

rs1799983 is a SNP (single nucleotide polymorphism) in the NOS3 (Nitric Oxide Synthase 3 (Endothelial)) gene. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. NOS3 encodes endothelial nitric oxide synthase (eNOS), which produces NO in endothelial cells to regulate vasodilation and platelet aggregation.

Biological role and pathway

This variant sits within the NOS3 gene, which is involved in the endothelial nitric oxide / vasodilation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NOS3

rs1799983 is one of 3 known variants in the NOS3 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1799983

Research into NOS3 variants including rs1799983 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NOS3 and the rs1799983 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the NOS3 gene

The following variants in NOS3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions