rs869109213
Variant in the NOS3 gene (Nitric Oxide Synthase 3 (Endothelial))
rs869109213 is a single nucleotide polymorphism (SNP) in the NOS3 gene, involved in endothelial nitric oxide / vasodilation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs869109213 variant?
rs869109213 is a SNP (single nucleotide polymorphism) in the NOS3 (Nitric Oxide Synthase 3 (Endothelial)) gene. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. NOS3 encodes endothelial nitric oxide synthase (eNOS), which produces NO in endothelial cells to regulate vasodilation and platelet aggregation.
Biological role and pathway
This variant sits within the NOS3 gene, which is involved in the endothelial nitric oxide / vasodilation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs869109213 and Long COVID / ME-CFS research
eNOS-derived NO maintains vascular homeostasis; NOS3 variants (Glu298Asp, VNTR intron 4) affect endothelial NO production and may contribute to microvascular dysfunction in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NOS3
rs869109213 is one of 3 known variants in the NOS3 gene. To understand the full biological context of this variant, explore the parent gene page.
View NOS3 gene page →Conditions studied in relation to rs869109213
Research into NOS3 variants including rs869109213 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NOS3 and the rs869109213 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NOS3 gene
The following variants in NOS3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs869109213 variant in the NOS3 gene?
rs869109213 is a single nucleotide polymorphism (SNP) located in the NOS3 (Nitric Oxide Synthase 3 (Endothelial)) gene, which is involved in endothelial nitric oxide / vasodilation. NOS3 encodes endothelial nitric oxide synthase (eNOS), which produces NO in endothelial cells to regulate vasodilation and platelet aggregation.
How may the rs869109213 variant relate to Long COVID or ME/CFS?
eNOS-derived NO maintains vascular homeostasis; NOS3 variants (Glu298Asp, VNTR intron 4) affect endothelial NO production and may contribute to microvascular dysfunction in Long COVID.
Can a consumer DNA test detect the rs869109213 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs869109213 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NOS3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Circulation
- [3]Nature Genetics