rs1800566
Variant in the NQO1 gene (NAD(P)H Quinone Dehydrogenase 1)
rs1800566 is a single nucleotide polymorphism (SNP) in the NQO1 gene, involved in antioxidant response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1800566 variant?
rs1800566 is a SNP (single nucleotide polymorphism) in the NQO1 (NAD(P)H Quinone Dehydrogenase 1) gene. It belongs to the Metabolism category and is part of the Oxidative Stress & Antioxidants biological cluster. NQO1 is a cytosolic flavoenzyme that performs two-electron reduction of quinones to hydroquinones, protecting against oxidative stress and participating in the antioxidant response. The rs1800566 variant encodes an unstable protein.
Biological role and pathway
This variant sits within the NQO1 gene, which is involved in the antioxidant response pathway. Genes within the Oxidative Stress & Antioxidants cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1800566 and Long COVID / ME-CFS research
NQO1 rs1800566 (Pro187Ser) dramatically reduces NQO1 protein stability and antioxidant capacity. Long COVID involves oxidative stress, and individuals homozygous for this variant may have impaired quinone detoxification and altered NAD+ metabolism relevant to fatigue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NQO1
rs1800566 is one of 3 known variants in the NQO1 gene. To understand the full biological context of this variant, explore the parent gene page.
View NQO1 gene page →Conditions studied in relation to rs1800566
Research into NQO1 variants including rs1800566 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NQO1 and the rs1800566 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NQO1 gene
The following variants in NQO1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1800566 variant in the NQO1 gene?
rs1800566 is a single nucleotide polymorphism (SNP) located in the NQO1 (NAD(P)H Quinone Dehydrogenase 1) gene, which is involved in antioxidant response. NQO1 is a cytosolic flavoenzyme that performs two-electron reduction of quinones to hydroquinones, protecting against oxidative stress and participating in the antioxidant response. The rs1800566 variant encodes an unstable protein.
How may the rs1800566 variant relate to Long COVID or ME/CFS?
NQO1 rs1800566 (Pro187Ser) dramatically reduces NQO1 protein stability and antioxidant capacity. Long COVID involves oxidative stress, and individuals homozygous for this variant may have impaired quinone detoxification and altered NAD+ metabolism relevant to fatigue.
Can a consumer DNA test detect the rs1800566 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1800566 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NQO1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29248780
- [2]Free Radical Biology and Medicine
- [3]Carcinogenesis