rs2695759
Variant in the NRP1 gene (Neuropilin 1)
rs2695759 is a single nucleotide polymorphism (SNP) in the NRP1 gene, involved in SARS-CoV-2 co-receptor / VEGF co-receptor. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2695759 variant?
rs2695759 is a SNP (single nucleotide polymorphism) in the NRP1 (Neuropilin 1) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. NRP1 encodes neuropilin-1, a co-receptor for VEGF-A and SEMA3A, and a host co-receptor enhancing SARS-CoV-2 cell entry at the furin-cleaved spike S1 CendR motif.
Biological role and pathway
This variant sits within the NRP1 gene, which is involved in the SARS-CoV-2 co-receptor / VEGF co-receptor pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2695759 and Long COVID / ME-CFS research
NRP1 enhances SARS-CoV-2 infectivity in neurons and olfactory epithelium; variants may affect viral neuroinvasion and contribute to neurological symptoms including anosmia in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NRP1
rs2695759 is one of 1 known variant in the NRP1 gene. To understand the full biological context of this variant, explore the parent gene page.
View NRP1 gene page →Conditions studied in relation to rs2695759
Research into NRP1 variants including rs2695759 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NRP1 and the rs2695759 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs2695759 variant in the NRP1 gene?
rs2695759 is a single nucleotide polymorphism (SNP) located in the NRP1 (Neuropilin 1) gene, which is involved in SARS-CoV-2 co-receptor / VEGF co-receptor. NRP1 encodes neuropilin-1, a co-receptor for VEGF-A and SEMA3A, and a host co-receptor enhancing SARS-CoV-2 cell entry at the furin-cleaved spike S1 CendR motif.
How may the rs2695759 variant relate to Long COVID or ME/CFS?
NRP1 enhances SARS-CoV-2 infectivity in neurons and olfactory epithelium; variants may affect viral neuroinvasion and contribute to neurological symptoms including anosmia in Long COVID.
Can a consumer DNA test detect the rs2695759 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2695759 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NRP1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]Science
- [3]Nature