NRP1 Gene

What is the NRP1 gene?

NRP1 encodes neuropilin 1, a protein involved in SARS-CoV-2 co-receptor / VEGF co-receptor. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. NRP1 encodes neuropilin-1, a co-receptor for VEGF-A and SEMA3A, and a host co-receptor enhancing SARS-CoV-2 cell entry at the furin-cleaved spike S1 CendR motif.

Biological role and pathway

NRP1 is involved in the SARS-CoV-2 co-receptor / VEGF co-receptor pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the NRP1 gene have been studied in relation to antiviral and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs2695759— NRP1 variant

Conditions studied in relation to NRP1

Research into NRP1 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that NRP1 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NRP1 and related genes in the viral defense & interferon response pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Viral Defense & Interferon Response pathway

NRP1 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions