rs849563

What is the rs849563 variant?

rs849563 is a SNP (single nucleotide polymorphism) in the NRP2 (Neuropilin 2) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. NRP2 encodes neuropilin-2, which functions as a co-receptor for VEGF-C and semaphorins, and may facilitate SARS-CoV-2 entry in some cell types.

Biological role and pathway

This variant sits within the NRP2 gene, which is involved in the VEGF co-receptor / axon guidance pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NRP2

rs849563 is one of 1 known variant in the NRP2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs849563

Research into NRP2 variants including rs849563 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NRP2 and the rs849563 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions