rs1052133

What is the rs1052133 variant?

rs1052133 is a SNP (single nucleotide polymorphism) in the OGG1 (8-Oxoguanine DNA Glycosylase) gene. It belongs to the Genome Stability category and is part of the Oxidative Stress biological cluster. OGG1 encodes the primary repair enzyme for 8-oxoguanine, the most common oxidative DNA lesion generated by reactive oxygen species.

Biological role and pathway

This variant sits within the OGG1 gene, which is involved in the base excision repair of oxidative DNA damage pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: OGG1

rs1052133 is one of 1 known variant in the OGG1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1052133

Research into OGG1 variants including rs1052133 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include OGG1 and the rs1052133 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions