rs2254298
Variant in the OXTR gene (Oxytocin Receptor)
rs2254298 is a single nucleotide polymorphism (SNP) in the OXTR gene, involved in oxytocin signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2254298 variant?
rs2254298 is a SNP (single nucleotide polymorphism) in the OXTR (Oxytocin Receptor) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. OXTR encodes the oxytocin receptor, through which oxytocin mediates prosocial behavior, stress responses, and anti-inflammatory effects.
Biological role and pathway
This variant sits within the OXTR gene, which is involved in the oxytocin signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2254298 and Long COVID / ME-CFS research
OXTR-mediated oxytocin signaling has immunomodulatory effects; variants may influence stress resilience and autonomic regulation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: OXTR
rs2254298 is one of 2 known variants in the OXTR gene. To understand the full biological context of this variant, explore the parent gene page.
View OXTR gene page →Conditions studied in relation to rs2254298
Research into OXTR variants including rs2254298 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include OXTR and the rs2254298 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the OXTR gene
The following variants in OXTR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2254298 variant in the OXTR gene?
rs2254298 is a single nucleotide polymorphism (SNP) located in the OXTR (Oxytocin Receptor) gene, which is involved in oxytocin signaling. OXTR encodes the oxytocin receptor, through which oxytocin mediates prosocial behavior, stress responses, and anti-inflammatory effects.
How may the rs2254298 variant relate to Long COVID or ME/CFS?
OXTR-mediated oxytocin signaling has immunomodulatory effects; variants may influence stress resilience and autonomic regulation in Long COVID.
Can a consumer DNA test detect the rs2254298 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2254298 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for OXTR and its variants. This is not an exhaustive literature review.
- [1]PMID: 32272069
- [2]Nature Genetics
- [3]Journal of Clinical Investigation