rs2268498

What is the rs2268498 variant?

rs2268498 is a SNP (single nucleotide polymorphism) in the OXTR (Oxytocin Receptor) gene. It belongs to the Neuroendocrine category and is part of the Neurological & Cognitive Function biological cluster. OXTR encodes the oxytocin receptor, mediating the effects of oxytocin on social bonding, pain modulation, uterine contraction, and autonomic regulation.

Biological role and pathway

This variant sits within the OXTR gene, which is involved in the social bonding / pain modulation / autonomic regulation pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: OXTR

rs2268498 is one of 2 known variants in the OXTR gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2268498

Research into OXTR variants including rs2268498 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include OXTR and the rs2268498 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the OXTR gene

The following variants in OXTR are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions