rs10935838
Variant in the P2RY12 gene (Purinergic Receptor P2Y12)
rs10935838 is a single nucleotide polymorphism (SNP) in the P2RY12 gene, involved in platelet activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs10935838 variant?
rs10935838 is a SNP (single nucleotide polymorphism) in the P2RY12 (Purinergic Receptor P2Y12) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. P2Y12 is an ADP-activated Gi-coupled receptor on platelets that amplifies platelet aggregation and is the target of clopidogrel, prasugrel, and ticagrelor antiplatelet therapy. It is also expressed on microglia.
Biological role and pathway
This variant sits within the P2RY12 gene, which is involved in the platelet activation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs10935838 and Long COVID / ME-CFS research
P2Y12 mediates platelet activation by ADP and represents a key node in COVID-19-associated thrombosis. Variants affecting P2Y12 function or clopidogrel target binding may influence platelet hyperreactivity and the microthrombi characteristic of Long COVID vascular disease.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: P2RY12
rs10935838 is one of 3 known variants in the P2RY12 gene. To understand the full biological context of this variant, explore the parent gene page.
View P2RY12 gene page →Conditions studied in relation to rs10935838
Research into P2RY12 variants including rs10935838 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include P2RY12 and the rs10935838 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the P2RY12 gene
The following variants in P2RY12 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs10935838 variant in the P2RY12 gene?
rs10935838 is a single nucleotide polymorphism (SNP) located in the P2RY12 (Purinergic Receptor P2Y12) gene, which is involved in platelet activation. P2Y12 is an ADP-activated Gi-coupled receptor on platelets that amplifies platelet aggregation and is the target of clopidogrel, prasugrel, and ticagrelor antiplatelet therapy. It is also expressed on microglia.
How may the rs10935838 variant relate to Long COVID or ME/CFS?
P2Y12 mediates platelet activation by ADP and represents a key node in COVID-19-associated thrombosis. Variants affecting P2Y12 function or clopidogrel target binding may influence platelet hyperreactivity and the microthrombi characteristic of Long COVID vascular disease.
Can a consumer DNA test detect the rs10935838 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs10935838 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for P2RY12 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29545629
- [2]Blood
- [3]Nature Reviews Cardiology