rs5918
Variant in the P2RY12 gene (Purinergic Receptor P2Y12)
rs5918 is a single nucleotide polymorphism (SNP) in the P2RY12 gene, involved in ADP-mediated platelet activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5918 variant?
rs5918 is a SNP (single nucleotide polymorphism) in the P2RY12 (Purinergic Receptor P2Y12) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. P2RY12 encodes the platelet ADP receptor, the target of clopidogrel and ticagrelor antiplatelet drugs.
Biological role and pathway
This variant sits within the P2RY12 gene, which is involved in the ADP-mediated platelet activation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5918 and Long COVID / ME-CFS research
Platelet hyperactivation via P2RY12 contributes to microthrombus formation; variants affecting P2RY12 activity may influence platelet aggregation and thrombotic risk in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: P2RY12
rs5918 is one of 3 known variants in the P2RY12 gene. To understand the full biological context of this variant, explore the parent gene page.
View P2RY12 gene page →Conditions studied in relation to rs5918
Research into P2RY12 variants including rs5918 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include P2RY12 and the rs5918 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the P2RY12 gene
The following variants in P2RY12 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5918 variant in the P2RY12 gene?
rs5918 is a single nucleotide polymorphism (SNP) located in the P2RY12 (Purinergic Receptor P2Y12) gene, which is involved in ADP-mediated platelet activation. P2RY12 encodes the platelet ADP receptor, the target of clopidogrel and ticagrelor antiplatelet drugs.
How may the rs5918 variant relate to Long COVID or ME/CFS?
Platelet hyperactivation via P2RY12 contributes to microthrombus formation; variants affecting P2RY12 activity may influence platelet aggregation and thrombotic risk in Long COVID.
Can a consumer DNA test detect the rs5918 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5918 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for P2RY12 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]NEJM