rs662
Variant in the PON1 gene (Paraoxonase 1)
rs662 is a single nucleotide polymorphism (SNP) in the PON1 gene, involved in HDL-associated antioxidant / organophosphate hydrolysis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs662 variant?
rs662 is a SNP (single nucleotide polymorphism) in the PON1 (Paraoxonase 1) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. PON1 encodes paraoxonase 1, an HDL-associated enzyme with antioxidant and anti-atherogenic properties that hydrolyzes oxidized lipids.
Biological role and pathway
This variant sits within the PON1 gene, which is involved in the HDL-associated antioxidant / organophosphate hydrolysis pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs662 and Long COVID / ME-CFS research
PON1 protects against lipid oxidation and LDL oxidation; variants (Gln192Arg, Leu55Met) are associated with cardiovascular risk and oxidative stress, potentially relevant to Long COVID cardiovascular complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PON1
rs662 is one of 3 known variants in the PON1 gene. To understand the full biological context of this variant, explore the parent gene page.
View PON1 gene page →Conditions studied in relation to rs662
Research into PON1 variants including rs662 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PON1 and the rs662 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PON1 gene
The following variants in PON1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs662 variant in the PON1 gene?
rs662 is a single nucleotide polymorphism (SNP) located in the PON1 (Paraoxonase 1) gene, which is involved in HDL-associated antioxidant / organophosphate hydrolysis. PON1 encodes paraoxonase 1, an HDL-associated enzyme with antioxidant and anti-atherogenic properties that hydrolyzes oxidized lipids.
How may the rs662 variant relate to Long COVID or ME/CFS?
PON1 protects against lipid oxidation and LDL oxidation; variants (Gln192Arg, Leu55Met) are associated with cardiovascular risk and oxidative stress, potentially relevant to Long COVID cardiovascular complications.
Can a consumer DNA test detect the rs662 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs662 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PON1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34088393
- [2]Nature Genetics
- [3]Arteriosclerosis Thrombosis and Vascular Biology