rs2282669
Variant in the SIGLEC1 gene (Sialic Acid Binding Ig Like Lectin 1 (CD169))
rs2282669 is a single nucleotide polymorphism (SNP) in the SIGLEC1 gene, involved in macrophage virus sensing / restriction. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2282669 variant?
rs2282669 is a SNP (single nucleotide polymorphism) in the SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1 (CD169)) gene. It belongs to the Immune Signaling category and is part of the Viral Defense & Interferon Response biological cluster. SIGLEC1 encodes CD169, a macrophage receptor that captures sialylated viruses and activates antiviral immune responses.
Biological role and pathway
This variant sits within the SIGLEC1 gene, which is involved in the macrophage virus sensing / restriction pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2282669 and Long COVID / ME-CFS research
SIGLEC1/CD169 on monocytes is elevated in COVID-19 and is a biomarker of type I interferon signaling; variants may affect monocyte sensing of SARS-CoV-2 and macrophage activation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SIGLEC1
rs2282669 is one of 1 known variant in the SIGLEC1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SIGLEC1 gene page →Conditions studied in relation to rs2282669
Research into SIGLEC1 variants including rs2282669 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SIGLEC1 and the rs2282669 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs2282669 variant in the SIGLEC1 gene?
rs2282669 is a single nucleotide polymorphism (SNP) located in the SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1 (CD169)) gene, which is involved in macrophage virus sensing / restriction. SIGLEC1 encodes CD169, a macrophage receptor that captures sialylated viruses and activates antiviral immune responses.
How may the rs2282669 variant relate to Long COVID or ME/CFS?
SIGLEC1/CD169 on monocytes is elevated in COVID-19 and is a biomarker of type I interferon signaling; variants may affect monocyte sensing of SARS-CoV-2 and macrophage activation in Long COVID.
Can a consumer DNA test detect the rs2282669 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2282669 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SIGLEC1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]Nature Immunology
- [3]Journal of Immunology