rs3818292
Variant in the SIRT1 gene (Sirtuin 1)
rs3818292 is a single nucleotide polymorphism (SNP) in the SIRT1 gene, involved in NAD+ signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3818292 variant?
rs3818292 is a SNP (single nucleotide polymorphism) in the SIRT1 (Sirtuin 1) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. SIRT1 is an NAD+-dependent deacetylase that regulates diverse cellular processes including energy metabolism, stress responses, circadian rhythms, and aging. It deacetylates BMAL1 and PER2 to modulate clock function.
Biological role and pathway
This variant sits within the SIRT1 gene, which is involved in the NAD+ signaling pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3818292 and Long COVID / ME-CFS research
NAD+ depletion is hypothesized in Long COVID and ME/CFS. SIRT1 variants affecting NAD+ utilization efficiency may impair mitochondrial function, circadian regulation, and stress resilience in post-COVID recovery.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SIRT1
rs3818292 is one of 3 known variants in the SIRT1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SIRT1 gene page →Conditions studied in relation to rs3818292
Research into SIRT1 variants including rs3818292 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SIRT1 and the rs3818292 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SIRT1 gene
The following variants in SIRT1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3818292 variant in the SIRT1 gene?
rs3818292 is a single nucleotide polymorphism (SNP) located in the SIRT1 (Sirtuin 1) gene, which is involved in NAD+ signaling. SIRT1 is an NAD+-dependent deacetylase that regulates diverse cellular processes including energy metabolism, stress responses, circadian rhythms, and aging. It deacetylates BMAL1 and PER2 to modulate clock function.
How may the rs3818292 variant relate to Long COVID or ME/CFS?
NAD+ depletion is hypothesized in Long COVID and ME/CFS. SIRT1 variants affecting NAD+ utilization efficiency may impair mitochondrial function, circadian regulation, and stress resilience in post-COVID recovery.
Can a consumer DNA test detect the rs3818292 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3818292 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SIRT1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28889047
- [2]Nature
- [3]Cell Metabolism