rs10847593

What is the rs10847593 variant?

rs10847593 is a SNP (single nucleotide polymorphism) in the SLC7A11 (Solute Carrier Family 7 Member 11 (xCT)) gene. It belongs to the Metabolic category and is part of the Oxidative Stress biological cluster. SLC7A11 encodes the xCT transporter that imports cystine for glutathione synthesis, protecting against ferroptosis.

Biological role and pathway

This variant sits within the SLC7A11 gene, which is involved in the cystine/glutamate antiporter / glutathione synthesis pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SLC7A11

rs10847593 is one of 1 known variant in the SLC7A11 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs10847593

Research into SLC7A11 variants including rs10847593 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC7A11 and the rs10847593 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions