rs2070424
Variant in the SOD1 gene (Superoxide Dismutase 1)
rs2070424 is a single nucleotide polymorphism (SNP) in the SOD1 gene, involved in antioxidant defense. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2070424 variant?
rs2070424 is a SNP (single nucleotide polymorphism) in the SOD1 (Superoxide Dismutase 1) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. SOD1 encodes copper-zinc superoxide dismutase, the cytoplasmic enzyme that neutralizes superoxide radicals.
Biological role and pathway
This variant sits within the SOD1 gene, which is involved in the antioxidant defense pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2070424 and Long COVID / ME-CFS research
SOD1 activity influences overall cellular antioxidant capacity and may modulate oxidative stress levels in Long COVID neurological symptoms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SOD1
rs2070424 is one of 2 known variants in the SOD1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SOD1 gene page →Conditions studied in relation to rs2070424
Research into SOD1 variants including rs2070424 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SOD1 and the rs2070424 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SOD1 gene
The following variants in SOD1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2070424 variant in the SOD1 gene?
rs2070424 is a single nucleotide polymorphism (SNP) located in the SOD1 (Superoxide Dismutase 1) gene, which is involved in antioxidant defense. SOD1 encodes copper-zinc superoxide dismutase, the cytoplasmic enzyme that neutralizes superoxide radicals.
How may the rs2070424 variant relate to Long COVID or ME/CFS?
SOD1 activity influences overall cellular antioxidant capacity and may modulate oxidative stress levels in Long COVID neurological symptoms.
Can a consumer DNA test detect the rs2070424 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2070424 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SOD1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25122754
- [2]Nature Genetics
- [3]Journal of Clinical Investigation