rs4880

What is the rs4880 variant?

rs4880 is a SNP (single nucleotide polymorphism) in the SOD2 (Superoxide Dismutase 2) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. SOD2 encodes mitochondrial manganese superoxide dismutase, the primary defense enzyme against mitochondrial superoxide radicals.

Biological role and pathway

This variant sits within the SOD2 gene, which is involved in the antioxidant defense pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SOD2

rs4880 is one of 1 known variant in the SOD2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4880

Research into SOD2 variants including rs4880 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SOD2 and the rs4880 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions