rs3024941
Variant in the STAT5A gene (Signal Transducer and Activator of Transcription 5A)
rs3024941 is a single nucleotide polymorphism (SNP) in the STAT5A gene, involved in cytokine receptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3024941 variant?
rs3024941 is a SNP (single nucleotide polymorphism) in the STAT5A (Signal Transducer and Activator of Transcription 5A) gene. It belongs to the Immune Signaling category and is part of the JAK-STAT Pathway biological cluster. STAT5A mediates signaling from growth hormone, prolactin, and many cytokines including IL-2 and IL-7.
Biological role and pathway
This variant sits within the STAT5A gene, which is involved in the cytokine receptor signaling pathway. Genes within the JAK-STAT Pathway cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3024941 and Long COVID / ME-CFS research
STAT5A-mediated IL-2 signaling is essential for regulatory T cell maintenance; variants may affect Treg function in Long COVID autoimmune complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: STAT5A
rs3024941 is one of 1 known variant in the STAT5A gene. To understand the full biological context of this variant, explore the parent gene page.
View STAT5A gene page →Conditions studied in relation to rs3024941
Research into STAT5A variants including rs3024941 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include STAT5A and the rs3024941 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the STAT5A gene
The following variants in STAT5A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3024941 variant in the STAT5A gene?
rs3024941 is a single nucleotide polymorphism (SNP) located in the STAT5A (Signal Transducer and Activator of Transcription 5A) gene, which is involved in cytokine receptor signaling. STAT5A mediates signaling from growth hormone, prolactin, and many cytokines including IL-2 and IL-7.
How may the rs3024941 variant relate to Long COVID or ME/CFS?
STAT5A-mediated IL-2 signaling is essential for regulatory T cell maintenance; variants may affect Treg function in Long COVID autoimmune complications.
Can a consumer DNA test detect the rs3024941 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3024941 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for STAT5A and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation