rs6503691

What is the rs6503691 variant?

rs6503691 is a SNP (single nucleotide polymorphism) in the STAT5A (Signal Transducer And Activator Of Transcription 5A) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. STAT5A mediates signaling downstream of IL-2, prolactin, and growth hormone, regulating T cell proliferation and Treg function.

Biological role and pathway

This variant sits within the STAT5A gene, which is involved in the IL-2 / prolactin / growth hormone signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: STAT5A

rs6503691 is one of 1 known variant in the STAT5A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs6503691

Research into STAT5A variants including rs6503691 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include STAT5A and the rs6503691 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the STAT5A gene

The following variants in STAT5A are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions