rs324011

What is the rs324011 variant?

rs324011 is a SNP (single nucleotide polymorphism) in the STAT6 (Signal Transducer And Activator Of Transcription 6) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. STAT6 mediates transcriptional responses to IL-4 and IL-13, driving Th2 differentiation, IgE production, and airway inflammation.

Biological role and pathway

This variant sits within the STAT6 gene, which is involved in the IL-4/IL-13 downstream signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: STAT6

rs324011 is one of 2 known variants in the STAT6 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs324011

Research into STAT6 variants including rs324011 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include STAT6 and the rs324011 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the STAT6 gene

The following variants in STAT6 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions