rs703817

What is the rs703817 variant?

rs703817 is a SNP (single nucleotide polymorphism) in the STAT6 (Signal Transducer and Activator of Transcription 6) gene. It belongs to the Immune Signaling category and is part of the JAK-STAT Pathway biological cluster. STAT6 mediates IL-4 and IL-13 signals, driving IgE class switching, Th2 differentiation, and mast cell-promoting responses.

Biological role and pathway

This variant sits within the STAT6 gene, which is involved in the IL-4 and IL-13 signaling pathway. Genes within the JAK-STAT Pathway cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: STAT6

rs703817 is one of 2 known variants in the STAT6 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs703817

Research into STAT6 variants including rs703817 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include STAT6 and the rs703817 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the STAT6 gene

The following variants in STAT6 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions