rs1131769

What is the rs1131769 variant?

rs1131769 is a SNP (single nucleotide polymorphism) in the STING1 (Stimulator Of Interferon Response CGAMP Interactor 1) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. STING1 encodes STING (Stimulator of Interferon Genes), the adaptor protein downstream of cGAS that activates TBK1/IRF3/NF-kB to induce type I interferons.

Biological role and pathway

This variant sits within the STING1 gene, which is involved in the cGAS-STING innate immune signaling pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: STING1

rs1131769 is one of 2 known variants in the STING1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1131769

Research into STING1 variants including rs1131769 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include STING1 and the rs1131769 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the STING1 gene

The following variants in STING1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions